基质血管组分治疗糖尿病慢性创面的有效性及进展
Effectiveness and progress of stromal vascular fraction in treating diabetic chronic wounds
彭璐璐 1曾田雨 1何明杰 1许荣2
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学第一附属医院内分泌科,江西 赣州 341000
- 折叠
摘要
糖尿病是一种较为严重的代谢性疾病,尤其是其复杂的并发症,给人类带来了严重的经济负担.糖尿病性伤口容易形成慢性不愈合性创面,并有复发的倾向,甚至可能导致截肢.传统的治疗方法效果欠佳,近年来以细胞为基础的治疗方法已经成为治疗糖尿病慢性创面的新措施.干细胞中的基质血管组分(Stromal vascular fraction,SVF)能分泌多种生长因子和趋化因子,有促进创面周围血管再生和抗炎的作用,糖尿病慢性创面可以实现血液循环的重建和血液补给,最终达到治愈糖尿病慢性创面的目的.本文从SVF促进糖尿病慢性创面愈合的疗效及可能的作用机制进行综述,同时指出SVF在再生医学中的应用前景.
Abstract
Diabetes mellitus is a relatively serious metabolic disease,especially its complex complications cause heavy economic burden.Diabetic wounds tend to cause chronic non-healing wounds,with a tendency to relapse,even possibly lead to amputation.In recent years,cell-based therapies have become a new approach to treat diabetic chronic wounds due to the poor effectiveness of traditional treatments.The stromal vascular fraction(SVF)in stem cells can secrete a variety of growth factors and chemokines,which can promote the regeneration of blood vessels around the wound and play an anti-inflammatory role.In this way,the diabetic chronic wound can achieve the reconstruction of blood circulation and the improvement of blood supply,and finally achieve the purpose of curing the diabetic chronic wound.This paper will review the efficacy and possible mechanism of SVF in promoting the healing of chronic diabetic wounds,and discuss the application prospect of SVF in regenerative medicine.
关键词
基质血管组分/慢性创面/糖尿病Key words
Stromal vascular fraction/Chronic wound/Diabetes mellitus引用本文复制引用
基金项目
江西省卫生健康委科技项目(202210870)
江西省教育厅科学技术研究项目(GJJ2201434)
出版年
2024
国家科技期刊平台
NSTL
万方数据