葡萄球菌性烫伤样皮肤综合征的研究进展
Research progress of staphylococcal scaled skin syndrome
张睿 1尤聪 2李龙年 2叶小英2
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学第一附属医院皮肤性病科 国家皮肤与免疫性疾病临床研究中心分中心建设单位,江西 赣州 341000
- 折叠
摘要
葡萄球菌性烫伤样皮肤综合征(Staphylococcal scaled skin syndrome,SSSS)是一种潜在的、危及生命的急性表皮剥脱综合征.本病主要是由凝固酶阳性第Ⅱ组噬菌体金黄色葡萄球菌感染引起的皮肤病.SSSS的诊断主要根据临床表现,包括全身泛发性红斑、松弛性大疱、烫伤样表皮剥脱、口周放射性皲裂、尼氏征阳性以及黏膜不受累及.目前SSSS的治疗主要以抗金黄色葡萄球菌的抗生素为主,包括耐青霉素酶青霉素类、头孢菌素类、万古霉素、克林霉素等.近年来SSSS发病率以及发生并发症和死亡的风险在不断增加,本文对近年来有关SSSS的研究进展进行综述,以期为提高医务工作者对SSSS的认知和诊疗能力提供参考.
Abstract
Staphylococcal scaled skin syndrome(SSSS)is a potentially life-threatening disorder and an acute epidermal exfoliation syndrome.The disease is caused by toxigenic strains of Staphylococcus aureus(S.aureus)which belongs to phage group Ⅱ and produces soluble toxin-exfoliative toxins.The diagnosis is mainly based on clinical manifestations,including erythroderma,bullae,desquamation with a scalded appearance,perioral crusting,positive Niskolsky sign,and absence of mucosal involvement.At present,the anti-S.aureus antibiotics are used for treatment of SSSS,including penicillinase-resistant penicillin,cephalosporin,vancomycin,clindamycin and other antibiotics.Both the incidence and the risk of complications and death of SSSS are increasing year by year.The research progress on SSSS in recent years is summarized in the present review to improve the knowledge of healthcare workers on SSSS.
关键词
葡萄球菌性烫伤样皮肤综合征/金黄色葡萄球菌/剥脱毒素/抗生素/治疗Key words
Staphylococcal scaled skin syndrome/Staphylococcus aureus/Exfoliative toxins/Antibiotics/Treatment引用本文复制引用
基金项目
国家自然科学基金地区科学基金项目(81960566)
出版年
2024