血浆致动脉粥样硬化指数与非酒精性脂肪性肝病的研究进展
Research progress on plasma atherogenic index and nonalcoholic fatty liver disease
高志宇 1谢军2
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学第一附属医院消化内科,江西 赣州 341000
- 折叠
摘要
非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)包括非酒精性脂肪肝、非酒精性脂肪性肝炎(Non-alcoholic steatohepatitis,NASH)和肝硬化.NAFLD相关疾病均始于脂肪变性,因此脂肪变性的早期识别有助于预防NASH和肝硬化,有研究表明血浆致动脉粥样硬化指数(Atherogenic index of plasma,AIP)与NAFLD密切相关.本文主要就AIP与NAFLD的研究进展进行综述,文献复习结果发现AIP可能通过脂质代谢紊乱、胰岛素抵抗、沉默调节蛋白1(Sirtuin 1,SIRT1)失活等与NAFLD相关联,AIP值高的人群NAFLD患病风险更高,AIP预测效能优于其他NAFLD生物标志物,可能为NAFLD的无创诊断提供参考.
Abstract
Nonalcoholic fatty liver disease(NAFLD)includes non-alcoholic fatty liver disease,non-alcoholic steatohepatitis(NASH)and cirrhosis.Since NAFLD-related disorders begin with steatosis,and early recognition of steatosis can help prevent the progression of NASH and fibrosis.Recent studies have shown that plasma-induced atherogenic index of plasma(AIP)is closely related to NAFLD.This article mainly reviews the non-invasive diagnostic evaluation methods of NAFLD and the research progress of AIP and NAFLD.The results of literature review show that AIP may be associated with NAFLD through lipid metabolism disorder,insulin resistance,SIRT1 inactivation,etc.People with high AIP values have a higher risk of NAFLD,and the predictive performance is better than that of other NAFLD biomarkers.It is hoped that it can provide a corresponding reference for the non-invasive diagnosis of NAFLD.
关键词
非酒精性脂肪性肝病/脂肪变性/血浆致动脉粥样硬化指数/无创诊断Key words
Nonalcoholic fatty liver disease/Steatosis/Plasma atherogenic index/Non-invasive diagnosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据