Objective:To conduct a meta-review of cases of subacute thyroiditis after novel coronavirus infection.Methods:A search was donefor case reports related to subacute thyroiditis after novel coronavirus infection published in PubMed,EMBASE,Cochrane Library and CNKI from November 2019 to December 2022.Complete data of author,coun-try,gender,clinical symptoms,nucleic acid detection,onset time,thyroid function and corresponding inflammatory indi-cators,thyroid ultrasound,thyroid iodine uptake rate or nuclide scanning,therapeutic drugs and thyroid function review were recorded,classified and listed for comparison.Results:Common features of the cases were fever,neck pain,low thyrotropin(TSH)levels,high FT4 and FT3 levels,and significantly elevated or normal inflammatory markers ESR and C-reactive protein(CRP).Thyroglobulin antibody(TGAb)and peroxidase antibody(TPO-Ab)were negative.Thyroid function returned to normal and symptoms resolved after 4 to 8 weeks of nonsteroidal and glucocorticoid therapy.Conclu-sion:After novel coronavirus infection,patients will develop subacute thyroiditis,which is mainly achieved through the affinity binding receptor reaction between the virus and the thyroid ACE2 receptor and the pituitary axis feedback path-way.The treatment is mainly based on glucocorticoids,reminding clinicians to pay attention to subthyroiditis after novel coronavirus infection.
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