High-flow nasal cannula oxygen therapy(HFNC)represents a novel non-invasive method of oxygen delivery that enables precise control over oxygen concentration and flow rate,while also featuring heating and humidification capabilities.This therapeutic approach enhances the oxygenation index(OI),reduces airway resistance,facilitates physiological dead space clearance,and offers positive end-expiratory pressure(PEEP)ventilation.Leveraging its distinctive functional attributes,HFNC rapidly ameliorates hypoxic conditions,thereby enhancing the safety of anesthesia induction and intubation.Despite its successful application in diverse clinical anesthesia settings,such as difficult airway management and non-invasive anesthesia,its utilization in anesthesia for endoscopic surgery is still in its nascent stage.This article summarizes the progress in applying HFNC during anesthesia for endoscopic procedures,providing valuable insights for refining the implementation of clinical anesthesia practices.