Objective:To investigate the feasibility and efficacy of low-dose rivaroxaban in the maintenance treatment of deep vein thrombosis.Methods:A total of 56 patients with deep vein thrombosis were divided into low-dose rivaroxaban treatment group(low-dose group)and conventional dose rivaroxaban treatment group(conventional dose group),with 28 cases in each group.The D-dimer level and lower limb diameter were compared between the two groups at admission(week 0)and at 1,2,3,4,8,12 weeks after treatment,and at admission(week 0)and at 3,4,8,12 weeks after treatment.The number of patients with pulmonary embolism and the frequency of bleeding events were also compared between the two groups.Results:There was no significant difference in D-dimer level or the circumference diameter of lower limbs between the two groups at different time points(P＞0.05);Pulmonary embolism occurred in 1 patient in the low-dose group and 3 patients in the conventional dose group,the difference was not statistically significant(P＞0.05);There were 2 bleeding events in the low-dose group(1 each for nose bleeding and gingival bleeding),and 8 bleeding events in the conventional dose group(3 for nose bleeding,3 for gingival bleeding and 2 for subcutaneous bleeding).The risk of bleeding in the conventional dose group was higher than that in the low-dose group,and the difference was statistically significant(P＜0.05).Conclusion:In the maintenance phase of lower limb deep vein thrombosis,low-dose and conventional-dose rivaroxaban have the same anticoagulant effect and do not increase the incidence of pulmonary embolism.In addition,the risk of bleeding events is lower.
维普
万方数据