Diabetic angiopathies,a common chronic complication of diabetes,has a high risk of thrombosis,accompanied by high mortality and disability rates.There is a complex relationship between diabetes vascular lesions and thrombosis,and although the current antithrombotic treatment has certain effect.But it will face challenges of bleeding,drug resistance because of the single action mechanism and long-term drug use.Innovative treatment strategies are urgently needed.Diabetes vascular lesions and thrombosis are closely related.The pathogenesis involves endothelial dysfunction,platelet activation and blood coagulation system activation,blood rheology change,inflammation,and many other aspects.The treatment of diabetes vascular lesions should take a comprehensive strategy,including the control of blood sugar,blood fat,the use of antiplatelet and anticoagulant drugs,to prevent and reduce the related complications.In this paper,the diabetes vascular lesions associated with thrombosis and antithrombotic treatment were reviewed.