赣南医学院学报2024,Vol.44Issue(8) :833-839.DOI:10.3969/j.issn.1001-5779.2024.08.016

糖尿病血管病变与血栓形成相关因素的研究进展

Research progress of related factors of diabetic angiopathy and thrombosis

许荣 何明杰 彭璐璐 陈芳 陈懿建
赣南医学院学报2024,Vol.44Issue(8) :833-839.DOI:10.3969/j.issn.1001-5779.2024.08.016

糖尿病血管病变与血栓形成相关因素的研究进展

Research progress of related factors of diabetic angiopathy and thrombosis

许荣 1何明杰 1彭璐璐 1陈芳 1陈懿建2
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作者信息

  • 1. 赣南医科大学第一附属医院内分泌科
  • 2. 赣南医科大学第一附属医院血液科,江西 赣州 341000
  • 折叠

摘要

糖尿病血管病变是糖尿病常见的慢性并发症,血栓形成的风险高,并伴随着高致死率和致残率.糖尿病血管病变与血栓形成之间关系复杂,并且目前的抗血栓治疗手段虽有一定成效,但面临药物出血倾向、作用机制单一及长期用药可能引发药物抵抗等挑战,亟须创新治疗策略.糖尿病血管病变与血栓形成之间的关系密切,其发病机制涉及内皮细胞功能障碍、血小板活化、凝血系统激活、血液流变学改变、炎症发生等多个方面.糖尿病血管病变的治疗需采取综合性策略,包括控制血糖、血脂,使用抗血小板与抗凝药物,以预防和减少相关并发症的发生.本文就糖尿病血管病变与血栓形成之间的关联以及抗血栓治疗进行探讨.

Abstract

Diabetic angiopathies,a common chronic complication of diabetes,has a high risk of thrombosis,accompanied by high mortality and disability rates.There is a complex relationship between diabetes vascular lesions and thrombosis,and although the current antithrombotic treatment has certain effect.But it will face challenges of bleeding,drug resistance because of the single action mechanism and long-term drug use.Innovative treatment strategies are urgently needed.Diabetes vascular lesions and thrombosis are closely related.The pathogenesis involves endothelial dysfunction,platelet activation and blood coagulation system activation,blood rheology change,inflammation,and many other aspects.The treatment of diabetes vascular lesions should take a comprehensive strategy,including the control of blood sugar,blood fat,the use of antiplatelet and anticoagulant drugs,to prevent and reduce the related complications.In this paper,the diabetes vascular lesions associated with thrombosis and antithrombotic treatment were reviewed.

关键词

糖尿病血管病变/血小板活化因子/凝血/血液流变学/炎症/血栓形成

Key words

Diabetic angiopathies/Platelet activation factor/Coagulation/Hemorheology/Inflammation/Thrombosis

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基金项目

江西省卫生健康委员会基金资助项目(202210870)

江西省教育厅科学技术研究项目(GJJ2201434)

江西省地方病(地中海贫血)临床研究中心项目(20223BCG74003)

出版年

2024
赣南医学院学报
赣南医学院

赣南医学院学报

影响因子:0.622
ISSN:1001-5779
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