赣南医学院学报2024,Vol.44Issue(8) :852-855,866.DOI:10.3969/j.issn.1001-5779.2024.08.019

布地奈德治疗新生儿呼吸窘迫综合征的研究进展

Research progress of budesonide in the treatment of neonatal respiratory distress syndrome

张珂 汪凌燕 仇鹏业 雷自成 饶兴愉
赣南医学院学报2024,Vol.44Issue(8) :852-855,866.DOI:10.3969/j.issn.1001-5779.2024.08.019

布地奈德治疗新生儿呼吸窘迫综合征的研究进展

Research progress of budesonide in the treatment of neonatal respiratory distress syndrome

张珂 1汪凌燕 1仇鹏业 1雷自成 1饶兴愉2
扫码查看

作者信息

  • 1. 赣南医科大学第一临床医学院
  • 2. 赣南医科大学第一附属医院儿童医学中心,江西 赣州 341000
  • 折叠

摘要

新生儿呼吸窘迫综合征(Neonatal respiratory distress syndrome,NRDS)的发病率、病死率均较高,是新生儿死亡的主要原因之一.NRDS早产儿目前主要的治疗方法为呼吸循环支持、肺表面活性物质(Pulmonary surfactant,PS)替代疗法等,但机械通气会增加患支气管肺发育不良(Bronchopulmonary dysplasia,BPD)或慢性肺病的风险.随着对NRDS的发病机制及治疗方法的不断深入研究,关于布地奈德(Budesonide,BUD)治疗NRDS的给药方式、用药剂量、用药频率没有统一的标准,且不同严重程度的NRDS治疗效果不同.本文就BUD治疗NRDS的研究进展进行综述,为NRDS治疗的基础及临床研究提供依据.

Abstract

Neonatal respiratory distress syndrome(NRDS)has a high morbidity and mortality rate.It is one of the leading causes of neonatal death.The current treatment for premature infants with NRDS is respiratory and circulatory support,pulmonary surfactant(PS)substitution therapy.However,mechanical ventilation increases the risk of developing bronchopulmonary dysplasia or chronic lung disease.With the continuous in-depth research on the pathogenesis and treatment methods of NRDS,there have been related research progress on the administration mode,dosage,and frequency of budesonide(BUD)treatment for NRDS.However,the treatment effect of NRDS varies with different severity levels,and there is no unified standard.This article reviews the research progress on BUD for NRDS to facilitate basic and clinical research on NRDS treatment.

关键词

布地奈德/新生儿呼吸窘迫综合征/支气管肺发育不良/炎症

Key words

Budesonide/Neonatal respiratory distress syndrome/Bronchopulmonary dysplasia/Inflammation

引用本文复制引用

出版年

2024
赣南医学院学报
赣南医学院

赣南医学院学报

影响因子:0.622
ISSN:1001-5779
段落导航相关论文