Neonatal respiratory distress syndrome(NRDS)has a high morbidity and mortality rate.It is one of the leading causes of neonatal death.The current treatment for premature infants with NRDS is respiratory and circulatory support,pulmonary surfactant(PS)substitution therapy.However,mechanical ventilation increases the risk of developing bronchopulmonary dysplasia or chronic lung disease.With the continuous in-depth research on the pathogenesis and treatment methods of NRDS,there have been related research progress on the administration mode,dosage,and frequency of budesonide(BUD)treatment for NRDS.However,the treatment effect of NRDS varies with different severity levels,and there is no unified standard.This article reviews the research progress on BUD for NRDS to facilitate basic and clinical research on NRDS treatment.