抗溃疡剂佐利米定及其含氟衍生物的合成研究
Study on the synthesis of antiulcer agent Zolimidine and its fluorinated derivatives
朱雪 1付鑫磊 1余树琴 1陈才博 1李镇霖 1郭小华 1杨凯1
作者信息
- 1. 赣南医科大学药学院,江西 赣州 341000
- 折叠
摘要
目的:探究抗溃疡剂佐利米定及其含氟衍生物的合成方法.方法:以2-氨基吡啶和2-溴-1-(4-甲磺酰基)苯乙酮为原料合成佐利米定,再分别与三氟乙醛水合物、三氟丙酮酸酯和二氟乙醛缩半乙醇反应,合成相应的含氟衍生物.结果:设计合成了佐利米定及其含氟衍生物,目标化合物经 1H NMR、13C NMR、19F NMR和高分辨质谱确证.结论:佐利米定及其含氟衍生物的合成方法具有工艺简单、产率高和操作方便等优点.
Abstract
Objective:To explore the synthesis of the antiulcer agent Zolimidine and its fluorinated derivative.Methods:Zolimidine was synthesized from 2-aminopyridine and 2-bromo-1-(4-methanesulfonyl)acetophenone,and then reacted with trifluoroacetaldehyde hydrate,trifluoromethylacetone esters,and difluoroacetaldehyde ethyl hemiacetal to synthesize corresponding fluorinated derivatives.Results:Zolimidine and its fluorinated derivatives were synthesized.The chemical structures of the target compounds were confirmed by 1H NMR,13C NMR,19F NMR and HR-MS.Conclusion:The synthesis methods of Zolimidine and its fluorinated derivatives has the advantages of simple process,high yield,and convenient operation.
关键词
佐利米定/有机合成/含氟化合物Key words
Zolimidine/Organic synthesis/Fluorine compounds引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据