Effect of compound azinomide in the treatment of severe erosive gastritis complicated with dyspepsia and influence on the recovery of gastric mucosa function
Objective:To study the effect of compound azinomide in the treatment of severe erosive gastritis complicated with dyspepsia and its effect on the recovery of gastric mucosa function.Methods:Ninety-seven patients admitted to Hebi People's Hospital from September 2021 to May 2023 were randomly divided into the conventional group(n=48)and the study group(n=49).The conventional group received conventional treatment,and the study group combined with compound azino-mide.Both groups received continuous treatment for 4 weeks.Data were collected.The pain degree,gastrointestinal function improvement time,gastrointestinal hormone level,gastric mucosal function and adverse reactions were compared between the two groups.Results:After treatment,the time of abdominal pain and distension elimination,VAS score,gastrointestinal singing restoring time and anal exhaust restoring time in the study group were(4.48±1.37)d,(2.08±0.68)scores,(3.91±0.89)d and(4.32±1.10)d,respectively,which were lower than these in the conventional group(5.29±1.50)d,(2.95±0.74)scores,(4.58±1.25)d,(5.02±1.35)d(P<0.01).After treatment,the levels of pepsinogen(PGⅡ,PGⅠ),gastrin-17(GAS-17)and 5-hydroxytryptamine(5-HT)in the study group were(17.02±3.51)μg/L,(134.25±11.60)μg/L,(7.62±2.38)pmol/L and(191.20±12.58)mg/L,respectively,which were higher than these in the conventional group(13.92±3.25)μg/L,(120.58±9.84)μg/L,(5.84±2.12)pmol/L,(178.69±14.60)mg/L(P<0.001).After treatment,the levels of basic fi-broblast growth factor(bFGF),antigen Ki-67 and epidermal growth factor(EGF)in the study group were(492.66±35.26)×103,97.69±8.46 and(349.84±22.65)×103,respectively,which were lower than(520.12±38.62)×103,103.54±9.85,(368.25±25.98)×103 in the conventional group(P<0.01).Conclusions:Compound azinomide treatment can effectively re-duce the pain degree of patients with severe vesicant gastritis complicated with dyspepsia,regulate the level of gastrointestinal hormone,protect gastric mucosa function,promote the recovery of gastrointestinal function,and have high safety.
Erosive gastritisCompound azinamideIndigestionGastrointestinal function
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