Observation on the changes and clinical significance study of serum T lymphocyte immunoglobulin mucin-3 and Golgi protein 73 in patients with hepatitis B virus infection related liver diseases
Objective:To observe the changes and clinical significance of serum T lymphocyte immunoglobulin mucin-3(TIM-3)and Golgi protein 73(GP73)in patients with hepatitis B virus(HBV)infection related liver diseases.Methods:A total of 100 patients with HBV infection related liver diseases treated in the 3rd People's Hospital of Zhengzhou from September 2020 to October 2022 were selected,including 47 cases of hepatitis B(CHB),35 cases of liver cirrhosis(LC),and 18 cases of hepatocellular carcinoma(HCC).They were included in the CHB,LC,and HCC groups.Another 30 healthy individuals who underwent physical examination in this hospital during the same period were included in the control group.According to the severity of the condition,the CHB group was subdivided into mild CHB group(n=16),moderate CHB group(n=19),and severe CHB group(n=12).The LC group was further subdivided into compensatory LC group(n=15)and decompensated LC group(n=20).The HCC group was subdivided into alpha fetoprotein(AFP)negative HCC group(n=8)and AFP positive HCC group(n=10).The levels of TIM-3,GP73,alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),and total bilirubin(TBil)in CHB group,LC group,HCC group and control group were compared.The levels of TIM-3 and GP73 in each subgroups(CHB sub-group,LC sub-group and HCC sub-group)were compared and their correlation with ALT,AST,ALB,and TBil in patients with HBV infection-related liver disease was analyzed.Results:The levels of TIM-3,GP73,ALT,AST,and TBil among the four groups(P＜0.05).The levels of TIM-3,GP73,ALT,AST and TBil in CHB,LC and HCC groups were higher than those in control group,and the albumin levels were lower than those in control group(P＜0.05).The levels of TIM-3,GP73,ALT,AST and TBil in LC group and HCC group were higher than those in CHB group,and the albumin levels were lower than those in CHB group(P＜0.05).TIM-3,GP73,ALT,AST and TBil levels in HCC group were higher than those in LC group,while albumin levels were lower than those in LC group(P＜0.05).The levels of TIM-3 and GP73 in mild CHB group,moderate CHB group and severe CHB group were significantly different(P＜0.05).TIM-3 and GP73 levels in moderate CHB group and severe CHB group were higher than those in mild CHB group(P＜0.05).TIM-3 and GP73 levels in severe CHB group were higher than those in moderate CHB group(P＜0.05).The levels of TIM-3 and GP73 in decompensated LC group were higher than those in compensated LC group(P＜0.05).The levels of TIM-3 and GP73 in the AFP positive HCC group were higher than those in the AFP negative HCC group(P＜0.05).TIM-3 and GP73 in CHB group,LC group,and HCC groups were positively correlated with ALT,AST,and TBil,while negatively correlated with albumin(P＜0.05).Conclusions:The levels of serum TIM-3 and GP73 are significantly elevated in patients with HBV infection related liver diseases,and the expression levels of CHB,LC,and HCC are significantly elevated at different stages of disease development,and are closely related to disease progression and liver function damage.
Hepatitis B virusChronic hepatitis BLiver cirrhosisHepatocellular carcinomaT lymphocyte immunoglobulin mucin-3Golgi protein 73
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