Study of maternal serum IgG antibody titer,neonatal reticulocyte and hemoglobin levels in early diagnosis of neonatal ABO hemolytic disease
Objective:To explore the application effect of maternal serum IgG antibody titer combined with neonatal Ret and Hb levels in the early diagnosis of ABO-HDN.Methods:A total of 102 pregnant women with normal delivery admitted to the First People's Hospital of Shangqiu from May 2021 to September 2023 were selected as the study objects.According to the newborn ABO-HDN screening results,the pregnant women and newborns were divided into ABO-HDN group(n=50)and non-ABO-HDN group(n=52).Serum IgG antibody titer,Ret and Hb levels of neonates in ABO-HDN group and non-ABO-HDN group were analyzed and compared.Receiver operating characteristic curve(ROC curve)was used to evaluate the efficacy of serum IgG antibody titer,neonatal Ret and Hb levels in the diagnosis of ABO-HDN.Results:The proportion of serum IgG antibody titer≥1:64 in ABO-HDN group was significantly higher than that in non-ABO-HDN group(P＜0.05).The Ret level in ABO-HDN group was significantly higher than that in non-ABO-HDN group,while Hb level was significantly lower than that in non-ABO-HDN group(P＜0.05).Area under the ROC curve(AUC)of serum IgG antibody titer in pregnant women,Ret and Hb levels in newborns were 0.826,0.725 and 0.657,respectively,and the AUC level of the three combined detection was 0.907,indicating the highest diagnostic value(P＜0.05).Conclusions:The serum IgG antibody titer of mothers before delivery and Ret and Hb levels of newborns are abnormal,and the combined detection of the three has a good diagnostic value in the early diagnosis of ABO-HDN.
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