Study on the application of LDH-5 and β2-MG in the diagnosis and efficacy assessment of diffuse large B-cell lymphoma
Objective:To analyze the application value of lactate dehydrogenase-5(LDH-5)and β2-microglobulin(β2-MG)in the diagnosis and efficacy assessment of diffuse large B-cell lymphoma(DLBCL).Methods:Eighty-seven DLBCL patients admitted to Clinical College of Oncology,Fujian Medical University from June 2020 to January 2023 were selected as the study group,and 120 healthy people who underwent physical examination in the outpatient department of the same hospital during the same period were selected as the control group.The expression of LDH-5 and β2-MG between the control group and the study group as well as patients with different clinicopathological characteristics of the study group were analyzed,and the receiver operating characteristic(ROC)curve was drawn to analyze the diagnosis value of LDH-5 and β2-MG levels in DLBCL.Spearman correlation analysis was used to analyze the correlation between LDH-5 and β2-MG and the response rate of DLBCL patients.Results:The levels of LDH-5 and β2-MG in the study group were significantly higher than those of the control group(P＜0.05).Treatment was effective in 72 of the 87 patients and ineffective in 15.The sensitivity,specificity,accuracy,and area under ROC curve(AUC,95%CI)values of the combined detection of LDH-5 and β2-MG levels for diagnosing DLBCL were 0.944,0.922,0.931,and 0.876(0.641-0.910),respectively,which were significantly higher than those of single indicator detection(P＜0.05).The levels of LDH-5 and β2-MG in Ann Arbor stage Ⅲ to Ⅳ,with bone marrow infiltration,ineffective treatment response,and international prognostic index(IPI)score at high risk were significantly higher than those in Ann Arbor stage Ⅰ to Ⅱ,without bone marrow infiltration,effective treatment response,and low risk IPI score,respectively(P＜0.05).The results of Pearson analysis showed that LDH-5 and β2-MG levels were negatively correlated with the treatment efficacy of DLBCL patients(P＜0.05).Conclusions:LDH-5 and β2-MG levels are highly expressed in DLBCL patients,and the combined detection of the above indexes can enhance the diagnosis value of DLBCL patients and provide clinical reference for the assessment of the prognosis and efficacy.
Lactate dehydrogenase-5β2-microglobulinDiffuse large B-cell lymphomaDiagnosis value
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