Analysis of the relationship between serum Hcy,urine ACR,dynamic pulse pressure index and earlyrenal damage in patients with essential hypertension
Objective:To investigate the relationship between serum homocysteine(Hcy),urine albumin-to-creatinine ratio(ACR),dynamic pulse pressure index(PPI)and early renal damage in patients with essential hypertension.Methods:A total of 105 patients with early renal damage caused by essential hypertension who were treated in the Second People'sHospital of Zhengzhou from January 2021 to January 2024 were selected as the observation group,and 98 patients with essential hypertension treated in the same hospital during the same period without renal damage were selected as the control group.Laboratory indicators(Hcy,ACR and PPI)and general clinical data of the two groups were compared.The risk factors of early renal damage in essential hypertension and the diagnostic value of Hcy,ACR and PPI in early renal damage in essential hypertension were analyzed by the receiver operating characteristic(ROC)curve.Patients in the observation group were dividedinto mild group,moderate group and severe group according to the glomerular filtration rate.Hcy,ACR and PPI in the three groups were compared.The relationship between above indicators and disease severity was discussed.Results:There were no significant differences in general clinical data,blood lipid and blood glucose between the observation group and the control group(P＞0.05),but there were statistically significant differences in Hcy,ACR and PPI between the two groups(P＜0.001).Logistic regression analysis showed that Hcy,ACR,and PPI were risk factors for early renal damage in essential hypertension(P＜0.05).ROC curves of Hcy,ACR,and PPI in the diagnosis of early renal damage were plotted,and the result showed that the areas under the curves were 0.713,0.723,and 0.611,respectively(P＜0.05).There were statistically significant differences in Hcy,ACR and PPIamong the mild group,the moderate group and the severe group(P＜0.05).Spearman correlation analysis showed that Hcy,ACR and PPI were positively correlated with the degreeof renal damage(P＜0.05).Conclusions:The elevated Hcy,ACR and PPI are risk factors for early renal damage in patients with essential hypertension,which are closely related to the degree of damage and can assist the diagnosis of early renal damage.
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