Changes and diagnostic value of blood urea,uric acid,creatinine and Cys-C in the process of kidney injury in patients with gestational hypertension
Objective:To investigate the trends of blood urea,uric acid,creatinine and Cys-C in the process of kidney injury in patients with hypertension in pregnancy,and to assess the value of the above indicators in the diagnosis of kidney injury.Methods:A total of 78 pregnant women with gestational hypertension and kidney injury admitted to Kaifeng People's Hospital from April 2021 to August 2023 were selected and retrospectively analyzed as the study group,and 71 pregnant women without kidney injury in patients with hypertensive disorders complicating pregnancy during the same period were selected as the control group.The levels of serum urea,uric acid,creatinine and Cys-C were compared between the two groups.The Logistic regression method was used to analyze whether UREA,uric acid,creatinine and Cys-C were the influential factors of early kidney injury.To analyze the sensitivity,specificity and accuracy of serum urea,uric acid,creatinine and Cys-C in the diagnosis of early kidney injury in pregnancy-induced hypertension.Results:The levels of urea,uric acid,creatinine and Cys-C were higher in the study group(P＜0.05).UREA,uric acid,creatinine and Cys-C were brought into the Logistic regression equation for calculation,and it was found that urea,uric acid,creatinine and Cys-C were the influencing factors in determining the appearance of early kidney injury(OR＞1,P＜0.05).The area under the curve(AUC),95%CI and sensitivity of the combined urea,uric acid,creatinine and Cys-C in the diagnosis of early kidney injury in hypertensive pregnancy were 0.880,0.828-0.933 and 76.92%,respectively,which were significantly higher than that of the single diagnosis(P＜0.05).Conclusions:Urea,uric acid,creatinine and Cys-C have important diagnostic value in patients with hypertension in pregnancy,and the combined detection can more accurately identify patients with early kidney injury,which can provide an important basis for early diagnosis and treatment for patients.
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