Changes and clinical significance of serum coagulation factor Ⅷ and anticoagulation factor in patients with hepatitis B virus infection-associated liver disease
Objective:To investigate the changes and clinical significance of serum coagulation factor Ⅷ and anticoagulation factor levels in patients with hepatitis B virus(HBV)infection-associated liver disease.Methods:A total of 113 patients with HBV infection-associated liver disease admitted to the Third People's Hospital of Zhengzhou from September 2020 to October 2022 were selected as the study objects,including 42 patients in the chronic hepatitis B group,26 patients in the cirrhosis compensation group,27 patients in the cirrhosis decompensation group,and 18 patients in the liver failure group.Four groups of coagulation factor Ⅷ,platelet count(PLT),prothrombin time(PT),activated partial thromboplastin time(APTT),von Willemeria factor antigen(vWF:Ag)and anticoagulant factor activity[antithrombin(A T),free protein S(FPS),protein C(PC)]activity were detected and compared.The correlation between anticoagulant factors and coagulation factors Ⅷ and levels of PLT,PT and APTT in patients with HBV infection-associated liver disease was analyzed.The independent risk factors affecting liver failure in patients with HBV infection-associated liver disease were analyzed with Logistic regression model,and receiver operating characteristic(ROC)curve was drawn to analyze diagnostic efficiency.Results:There were significant differences in the levels of coagulation factors Ⅷ,PLT,PT,APTT,vWF:Ag,AT,FPS,PC among the four groups(P＜0.001).Compared with chronic hepatitis B group,the levels of PT,APTT,vWF:Ag and coagulation factor Ⅷ were higher in cirrhosis compensation group,cirrhosis decompensation group and liver failure group,while the levels of PLT,AT,FPS and PC were lower(P＜0.05).In the compensation period of cirrhosis,with the aggravation of the disease,the level of coagulation factor Ⅷ,PT,APTT,vWF:Ag gradually increased,and the activity of anticoagulation factor continued to decrease(P＜0.05).Pearson correlation analysis showed that AT,FPS,PC were positively correlated with coagulation factor Ⅷ and PLT(P＜0.05),and negatively correlated with PT,APTT,vWF:Ag(P＜0.05).Multivariate analysis of Logistic regression model showed that coagulation factor Ⅷ(P=0.029,OR=1.061)level,AT(P=0.001,OR=1.059),FPS(P=0.014,OR=1.066),PC(P=0.001,OR=1.077)activity were independent factors for liver failure in patients with HBV infection-associated liver disease.ROC curve analysis showed that the area under the curve(AUC)value of the combined detection of coagulation factor Ⅷ,AT,FPS and PC in the diagnosis of liver failure was the highest,which was 0.966,and the sensitivity and specificity were 94.44%and 88.88%,respectively.Conclusions:The levels of coagulation factors such as coagulation factor Ⅷ and anticoagulation factors AT,FPS and PC in patients with HBV infection-associated liver disease at different stages have changed.With the aggravation of the disease,the higher the levels of coagulation factor Ⅷ,the lower the levels of AT,FPS,PC.At the same time,the combined detection of coagulation factor Ⅷ,AT,FPS,PC has a high diagnostic efficacy in the assessment of liver failure in patients with HBV infection.
Hepatitis B virusCoagulation factorAnticoagulant factorHepatic failure
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