Clinical effect of glucocorticoid combined with cyclophosphamide in the treatment of cerebral arteritis
Objective:To explore the effects of combined treatment of glucocorticoids and cyclophosphamide on the changes in inflammatory indexes and neurological function recovery in patients with cerebral arteritis.Methods:An analysis was performed on 93 patients with cerebral arteritis admitted to Henan General Hospital from March 2020 to June 2022.They were divided into the control group(given methylprednisolone sodium succinate,n=46)and the observation group(given methylprednisolone sodium succinate+cyclophosphamide,n=47)by random number method.The clinical efficacy,levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)],neurological recovery[National Institutes of Health Stroke Scale(NIHSS)]and Fugl-Meyer motor function assessment(FMA)scores],adverse reactions and recurrence rate were compared between the two groups.Results:The total effective rate and incidence of adverse reactions were 95.74% and 14.89% in the observation group,and 80.43% and 32.60% in the control group,respectively.Compared with the control group,the total effective rate in the observation group was higher and the incidence of adverse reactions was lower(P＜0.05).After 4 courses of treatment,compared with control group,the levels of IL-6,TNF-α,CRP and NIHSS in the observation group were lower,and the FMA score was higher(P＜0.01).There was no difference in recurrence rate between the two groups at each time point(P＞0.05).Conclusions:Glucocorticoid combined with cyclophosphamide can effectively improve the clinical efficacy of patients with cerebral arteritis,significantly improve the inflammatory response and neurological function,and has good safety.
Cerebral arteritisGlucocorticoidsCyclophosphamideInflammation indicatorsNeurological function
万方数据
维普
