The changes and clinical significance of MCP and cadherin levels before and after early endovascular treatment in patients with acute ischemic stroke due to large vessel occlusion
Objective:To investigate the changes of monocyte chemoattractant protein(MCP)and cadherin levels in patients with acute ischemic stroke due to large vessel occlusion(AIS-LVO)before and after early endovascular treatment and their clinical significance.Methods:A total of 72 patients with AIS-LVO admitted to the First Affiliated Hospital of Nanyang Medical College from May 2020 to May 2023 were selected.These patients were followed up for 3 months,and the prognosis was statistically analyzed according to the modified Rankin scale(mRS).The changes of MCP and cadherin levels before and after treatment were compared,the risk factors affecting the prognosis of AIS-LVO patients after early endovascular treatment were analyzed,and the effect of MCP and cadherin on predicting the prognosis of AIS-LVO patients after early endovascular treatment were calculated.Results:(1)After treatment,the levels of MCP and cadherin were significantly lower than those before treatment(P＜0.001).(2)All patients completed 3 months of follow-up,and 29 patients were found with good prognosis by mRS score,accounting for 40.28% .There were 43 cases of poor prognosis,accounting for 59.72% .(3)Early CT(ASPECTS)score,MCP and cadherin levels of Alberta Stroke Program were independent risk factors affecting the prognosis of AIS-LVO patients after early endovascular treatment(P＜0.05).(4)ROC curve showed that the sensitivity of combined detection of MCP and cadherin in predicting the prognosis of AIS-LVO patients after early endovascular therapy was 74.42%,specificity was 93.10%,AUC=0.876,sensitivity and AUC were higher than those of single prediction(P＜0.001).Conclusions:Early endovascular treatment can regulate the expression of MCP and cadherin in patients with AIS-LVO.By comprehensively evaluating the levels of the two indicators,the predictive effect on the prognosis of patients can be improved in order to achieve the purpose of improving the prognosis.
Monocyte chemoattractant proteinAcute ischemic stroke due to vessel occlusionCadherinAlberta Stroke Program Early CT ScoreInfluence factors
万方数据
维普
