铁皮石斛(Dendrobium officinale Kimura et Migo)是兰科石斛属多年生草本植物铁皮石斛的干燥茎,药用历史悠久,在我国南部地区广泛分布.研究表明铁皮石斛不同部位(叶、茎、花)富含黄酮、联苄、生物碱、苯丙素、萜、菲与核苷类化合物,具有显著的抗氧化、抗肿瘤、降血糖、缓解便秘、预防骨质疏松、护肝保肾等药理活性,在治疗恶性肿瘤、胃肠道疾病、糖尿病、白内障、关节炎、血栓闭塞性脉管炎及慢性咽炎等疾病有很好的疗效,特别是对于胃癌、肝癌、干眼症以及糖尿病等疾病的缓解作用比较显著.本文将铁皮石斛中报道的261种化合物、药理作用研究现状进行综述,以期为铁皮石斛后续研究开发参考.
Advance on chemical components and pharmacological effects of Dendrobium officinale
Tie-Pi Shihu,the dried stem of the perennial herb Dendrobium officinale in the genus Den-drobium of the family Orchidaceae,has a long history of medicinal usage and is widely distributed in the southern part of China.Researches showed that different parts(leaves,stems and flowers)of D.officinale are rich in flavonoids,bibenzyl,alkaloids,phenylpropanoids,terpenes,phenanthrene and nucleosides,which have significant pharmacological activities such as antioxidant,antitumor,hypoglycemic,constipation relief,osteoporosis prevention,liver and kidney protection,etc..They are very effective in treating malignant tu-mor,gastrointestinal diseases,diabetes,cataract,arthritis,thromboangiitis obliterans and chronic pharyngi-tis,etc.Particularly,it is effective in the treatments of gastric cancer,liver cancer,dry eye and diabetes.In this paper,the reported 261 compounds from Dendrobium officinale and the progress of research on pharma-cological effects are reviewed,providing the reference for subsequent research and development of Dendro-bium officinale.
万方数据
维普
