Scour actions tend to weaken the pile-soil interaction in railway bridges,amplifying seismic risk.Based on a high-speed railway continuous girder bridge,this study employed OpenSees to establish an integrated girder-track computational model,and examined the influence of ballast resistance coefficient and rail anchors on bridge seismic responses under varying scour depths.It further analyzed the effect of track constraints on bridge seismic responses and damping effectiveness,and explored the impact of non-uniform scour on bridge seismic behavior.Findings indicate:(1)The seismic response of bridges under different bearings exhibits strong dependence on the ballast resistance coefficient as scour depth varies;rail anchor structures significantly affect bridge seismic response under scour conditions.(2)Track constraints have a pronounced effect on the seismic response of bridges with conventional bearings subjected to scour,whereas their influence is less pronounced for bridges equipped with friction pendulum bearings.(3)Bridge damping efficiency decreases with increasing scour depth,and the influence of track constraints on damping becomes more substantial as scour deepens.(4)Non-uniform scour exerts a more pronounced influence on bridge seismic response compared to uniform scour under track constraints.These conclusions can serve as a reference for seismic design of railway bridges crossing river valleys.