Effects of bisphenol S exposure during adolescence on neurobehavior and anti-oxydation level of brain tissue in female mice
Objective To investigate the effects of bisphenol S(BPS)exposure on neurobehavior and anti-oxy-dation level in brain tissue of adolescent female mice.Methods 52 SPF grade female C57BL/6J mice aged 4 weeks were divided into control group and BPS low,medium and high dose groups by random number table method,with 13 mice in each group.After 8 weeks of exposure to different doses of BPS,the neurobehavioral indicators of mice were observed by open field test and Morris water maze test,and the activities of malondialdehyde(MDA),su-peroxide dismutase(SOD),glutathione peroxidase(GSH-Px)and catalase(CAT)were detected.Results The open field test showed that the anxiety and spontaneous activity of adolescent female mice exposed to BPS had no statisti-cal significance compared with the control group(P＞0.05).The results of Morris water maze test showed that except the escape latency of the medium dose group of BPS on day 5 was significantly shorter than that in the other 3 groups(P＜0.05),there were no other significant differences in adult learning and memory function between adoles-cent female mice exposed to BPS and the control group(P＞0.05).There were no significant differences in oxidative stress indexes(MDA,SOD,GSH-Px,CAT)between adolescent female mice exposed to BPS and the control group(P＞0.05).Conclusion BPS exposure during adolescence has no significant effect on the neurobehavior of female mice,and does not cause significant oxidative stress in the brain of mice.
bisphenol Sadolescencefemale miceoxidative stressneurobehaviorexperimental research
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