羟丙基甲基纤维素改善栀子水提物流动性实验研究
Experimental study on improving fluidity of Gardenia Fructus aqueous extract by HPMC
闫渊 1韩建鹏 1周彩娟 1杨琪 2孙萍3
作者信息
- 1. 江西中医药大学药学院,江西 南昌 330004
- 2. 江中药业股份有限公司研发中心,江西 南昌 330103
- 3. 江西中医药大学药学院,江西 南昌 330004;江中药业股份有限公司研发中心,江西 南昌 330103
- 折叠
摘要
目的 研究羟丙基甲基纤维素(HPMC)对栀子水提物流动性的影响.方法 采用单因素试验分别考察HPMC含量及固含量的范围,再以中心复合试验考察HPMC含量和固含量对HPMC-栀子水提物复合粒子流动性的影响.结果 以休止角作为流动性的考察指标,得最优处方为:HPMC用量8.45％,喷雾物料固含量19.08％;对模型的预测值进行验证,预测值与实测值的误差较小,为0.58％;栀子水提物的休止角为34.8°.结论 加入一定量的HPMC与栀子水提物进行共喷雾干燥,可解决栀子水提物流动性差的问题.
Abstract
Objective To study the effect of hydroxypropyl methylcellulose(HPMC)on the fluidity of aqueous extract of Gardenia Fructus.Methods The single factor test was used to investigate the range of HPMC content and solid content,and then the central composite test was used to investigate the effect of HPMC content and solid content on the fluidity of HPMC-Gardenia aqueous extract composite particles.Results Taking the angle of reposi-tion as the fluidity index,the optimal prescription was:the amount of HPMC 8.45％,the solid content of spray mate-rial 19.08％;the predicted value of the model is verified,and the error between the predicted value and the mea-sured value is 0.58％.The repose angle of the water extract of Gardenia Fructus was 34.8°.Conclusion By adding a certain amount of HPMC and gardenia water extract for co-spray drying,the problem of poor flow of gardenia water extract can be solved.
关键词
栀子水提物/羟丙基甲基纤维素/喷雾干燥/流动性/休止角/粒径Key words
aqueous extract of gardenia/hydroxypropyl methyl cellulose(HPMC)/spray drying/liquidity/angle of repose/particle size引用本文复制引用
基金项目
国家重点研发计划项目(2018YFB140430503)
江西省重大科技研发专项(20203ABC28W018)
出版年
2024
国家科技期刊平台
NSTL
万方数据