Experimental study on improving fluidity of Gardenia Fructus aqueous extract by HPMC
Objective To study the effect of hydroxypropyl methylcellulose(HPMC)on the fluidity of aqueous extract of Gardenia Fructus.Methods The single factor test was used to investigate the range of HPMC content and solid content,and then the central composite test was used to investigate the effect of HPMC content and solid content on the fluidity of HPMC-Gardenia aqueous extract composite particles.Results Taking the angle of reposi-tion as the fluidity index,the optimal prescription was:the amount of HPMC 8.45％,the solid content of spray mate-rial 19.08％;the predicted value of the model is verified,and the error between the predicted value and the mea-sured value is 0.58％.The repose angle of the water extract of Gardenia Fructus was 34.8°.Conclusion By adding a certain amount of HPMC and gardenia water extract for co-spray drying,the problem of poor flow of gardenia water extract can be solved.
aqueous extract of gardeniahydroxypropyl methyl cellulose(HPMC)spray dryingliquidityangle of reposeparticle size
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