Pharmacological mechanism exploration of Salviae przewalskii Maxim based on network pharmacology
Objective To analyze the pharmacological action and mechanism of Salviae przewalskii Maxim based on network pharmacology.Methods The active components of Salviae przewalskii Maxim were screened by using domestic and foreign databases combined with Traditional Chinese Medicine System Pharmacology Database and Analysis Platform(TCMSP),and the targets of active components were screened by using Swiss Target Predic-tion and Pharm Mapper databases.Comparative Toxicology Genomics(CTD)database was used to collect the rele-vant information of the target,and Cytoscape 3.8.2 software was used to construct the active ingredient-target,target-disease network,and protein-protein in teraction(PPI)network of the target was constructed through STRING 11.5 database.Finally,DAVID and Bioconductor databases were used to analyze the target gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG),and the target-pathway network was constructed.Results A total of 26 active components were selected from Salviae przewalskii Maxim,and 218 targets were identified.There were 233 GO functional enrichment results,which mainly involved drug binding,adenosine triphosphate(ATP)binding and steroid binding.It showed 161 KEGG pathway enrichment results,mainly involved in cancer,cardiovascular system,nervous system,endocrine system and other signaling pathways.Conclusion This study described the pharmacolo-gical action and mechanism of Salviae przewalskii Maxim from the whole and provided the basis and basis for further research on the molecular mechanism of pharmacological action of the medical plant.
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