Clinical observation of 40 patients with refractory heart failure treated with Lrh-BNP and levosimendan injection combined with conventional vasoactive drugs
Objective To observe the clinical efficacy of lyophilized recombinant human brain natriuretic pep-tide(Lrh-BNP)and levosimendan injection combined with conventional vasoactive drugs in the treatment of refrac-tory heart failure.Methods 80 patients with refractory heart failure were randomly divided into a control group and a treatment group by computer permutation method,with 40 cases in each.The control group was treated with con-ventional vasoactive drugs,while the treatment group was administered Lrh-BNP in combination with levosimendan injection on the basis of the treatment approach of the control group.After treatment,the levels of cardiac function indices[creatine kinase(CK),creatine kinase isoenzyme-MB(CK-MB),lactate dehydrogenase(LDH),B-type na-triuretic peptide precursor(Pro-BNP)]before and after treatment were compared between the two groups.The oc-currence of adverse reactions during treatment was recorded for both groups,and the total incidence of adverse reac-tions was compared between the two groups.Results The serum levels of CK,CK-MB,LDH,and Pro-BNP in both groups were significantly reduced after treatment,and the differences were statistically significant compared with those before treatment(P＜0.01).The reduction was more pronounced in the treatment group,and the differences were statistically significant compared with the control group after treatment(P＜0.01).The total incidence of ad-verse reactions was 12.5％(5/40)in the control group and 10.0％(4/40)in the treatment group,and there was no statistical significance between the two groups(P＞0.05).Conclusion The combination of Lrh-BNP with levosi-mendan injection and conventional vasoactive drugs is effective in the treatment of refractory heart failure,and it can effectively improve the cardiac function of patients with manageable side effects and high safety,which is worthy of clinical promotion and application.
refractory heart failurelyophilized recombinant human brain natriuretic peptide(Lrh-BNP)levosi-mendan injectioncardiac function indexclinical effectadverse reaction
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