After conducting a comprehensive review of the literature and summarizing relevant clinical research on decorin's impact on lung cancer,digestive system malignant tumors,urinary system malignant tumors,and other malignant tumors,it is evident that decorin has the ability to inhibit the growth of malignant tumor cells from various tissue sources.This inhibition occurs whether decorin is overexpressed in vivo or used as a recombinant protein.The decorin gene shows promise as a potential target for clinical treatment of different types of malignant tumors.Addi-tionally,decorin has significant potential as a novel drug for treating both primary and metastatic cancers.Extracting and artificially synthesizing decorin to treat tumors through appropriate pathways represents an important direction for future research in this field.