Objective To observe the preventive impact of Qingdai Jinzhi Jianmei Cream(青黛紧致健美霜)on obesity in rats,particularly abdominal obesity,and to assess its efficacy in weight reducing.Methods 42 SPF male SD rats were divided into six groups(seven in each group)by the random number table method:normal control group,model control group,blank matrix group,Qingdai Jinzhi Jianmei Cream low-dose,medium-dose,and high-dose groups.The normal control group was provided with regular maintenance feed,while the other groups were fed high-fat feed to induce obesity.Simultaneously,the rats in the drug groups had Qingdai Jinzhi Jianmei Cream evenly applied to the skin surface of the abdominal hair removal area,followed by a one-minute massage after application,and the administration continued for nine weeks.By observing the alterations in body mass,neck and waist circum-ference,Lee's index,lipid-body ratio,blood fat level,liver coefficient,and histopathology of the rats,the effect of Qingdai Jinzhi Jianmei Cream on weight reducing was investigated.Results Compared with the normal control group,the change rate of body mass in the model control group was significantly elevated,and the difference was sta-tistically significant(P＜0.05).The body mass of rats in the drug groups increased at a slower pace,and the change rate of body mass in the medium and high-dose groups was significantly lower than that in the model control group(P＜0.05).Compared with the normal control group,the waist circumference of rats in the model control group was significantly increased,and Lee's index,liver coefficient,and lipid-body ratio were significantly elevated,and the differences were statistically significant(P＜0.05).Compared with the model control group,the waist circumference of rats in the high-dose group was significantly reduced,and Lee's index and lipid-body ratio were significantly de-creased,which was statistically significant(P＜0.05).Compared with the normal control group,the levels of TG,TC,and LDL-C in the model control group were significantly increased,while the level of HDL-C was significantly de-creased,and the differences were statistically significant(P＜0.05).Compared with the model control group,the level of LDL-C in the high-dose group was significantly reduced,which was statistically significant(P＜0.05).Pathological observations of the liver and abdominal subcutaneous adipose tissue revealed that steatosis occurred in the liver of rats in the model control group,with a dense distribution of abdominal subcutaneous fat and enlarged fat cells.Qing-dai Jinzhi Jianmei Cream can significantly reduce the degree of liver steatosis and the size of abdominal subcuta-neous fat cells in obese rats.Conclusion Qingdai Jinzhi Jianmei Cream can ameliorate the obesity of rats,espe-cially abdominal obesity.Its effect on weight reducing is notable,and it has a certain effect of lowering blood fat.
维普
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