Exploration of the compatibility rationality and mechanism of Qudu Fangyi Fang(祛毒防疫方)based on the theory of traditional Chinese medicine and data mining
Objective To explore the compatibility rationality and mechanism of Qudu Fangyi Fang(祛毒防疫方)for the prevention and treatment of epidemic diseases.Methods The theory of traditional Chinese medicine was employed to analyze the properties,flavors,meridians,compatibility effects,and compatibility mechanisms of Qudu Fangyi Fang.Data mining and network pharmacology were utilized to predict and screen the action targets and pathways of 33 compounds in the Jiebiao group(解表组),Qingre group(清热组),and Xuanfei Huashi group(宣肺化 湿组).Based on data integration analysis,the functional characteristics and compatibility mechanism of this ap-proach were analyzed and explained.Results There were 80 targets and 68 pathways associated with 33 com-pounds in Qudu Fangyi Fang,which were mainly involved in inflammatory responses,immune responses,bacterial responses,defense responses,and virus responses.The Jiebiao,Qingre,and Xuanfei Huashi group had common tar-getand pathway groups,and each had its own emphasis,which could exert a synergistic effect.Conclusion The Jiebiao group can act on virus,inflammation,defense response,and other related targets.Besides the synergistic effect of the Qingre group and the Jiebiao group on the inflammatory reaction caused by the virus reaction,it can also directly inhibit various viruses.By enhancing the body's immunity,the Xuanfei Huashi group had synergistic effects with the Qingre group and the solution table group.The three groups had different emphases and were inter-related,which reflected the rationality of their compatibility.
万方数据
维普
