The effects of different segregation grades on the mechanical properties and corrosion resistance of WE43A magnesium alloy were studied by means of metallographic microscope and scanning electron mi-croscope observation,tensile test at room temperature,four-point bending fatigue test and electrochemical test.The results show that the segregation structure is mainly composed of continuous mesh Mg41Nd5 phase and smaller granular Mg24Y5 phase,and the segregation is mainly distributed at the grain boundary.When the segregation grade is less than PX4,the tensile strength and plasticity indexes of the WE43A magnesium alloy only decrease slightly.When the segregation grade is more than PX4,the tensile strength and plasticity indexes begin to decrease significantly,and the tensile strength,elongation and section shrinkage decrease by about 48%,81%,89%,respectively.The effect of segregation defects on the yield strength and elastic modulus of WE43A magnesium alloys is not obvious.The maximum reduction in fatigue life (lg) and fa-tigue limit is approximately 33% and 39%.With the increase of segregation grade,the corrosion potential of WE43A magnesium alloy is moving from-1.573 V to-1.432 V,and the corrosion current density in-creases from 2.090 × 10-5 A/cm2 to 2.467 × 10-3 A/cm2,with an order of magnitude span of 2.The corro-sion products of WE43A magnesium alloy in 3.5ω%NaCl solution are mainly MgO and MgCl2.