Clinical features of respiratory tract infection with rhinovirus and the risk factors of pneumonia and severe pneumonia
Objective To compare the clinical features of respiratory infections caused by different types of human rhinovirus(HRV)and assess the risk factors for pneumonia and severe pneumonia.Methods The acute respiratory infection patients in 35 sentinel hospitals in Beijing were surveyed based on Beijing Respiratory Pathogen Surveillance System.The questionnaires were used to collect epidemiological and clinical data of enrolled patients.Respiratory samples were collected to detect HRV nucleic acid,and genotyping was performed via VP4/2 sequencing.Logistic regression analysis,in combination with clinical and genotyping data,was used to identify risk factors pneumonia and severe pneumonia associated with HRV.Results From January 2018 to December 2022,462 HRV-positive cases were detected.The clinical data successfully obtained from 430 of the cases(including 145 upper respiratory infection cases,239 pneumonia cases,and 46 severe pneumonia cases).Genotypes were identified successfully in 359 cases,including HRV-A(247 cases),HRV-B(42 cases)and HRV-C(70 cases).However,the hospitalization rates for HRV-B and HRV-C infections were higher than those for HRV-A.Multivariable logistic regression analysis indicated that over 60 years old of age,increased C-reactive protein(CRP)levels,HRV type(HRV-B and HRV-C),and co-infection were the independent risk factors for HRV pneumonia while abnormal respiratory rate and low blood oxygen saturation were risk factors for severe HRV pneumonia.Conclusions No type-specific clinical symptom was observed among HRV-A,HRV-B,and HRV-C infections.The risk of developing pneumonia and the proportion of hospitalizations were higher for HRV-B and HRV-C infections compared to HRV-A.However,there were no significant differences in the risk of severe pneumonia among the three viruses.
Human rhinovirusPneumoniaSevere PneumoniaRisk Factors
NETL
NSTL
万方数据
