胎儿生长受限的病因及对患儿远期健康的影响
The Etiology of Fetal Growth Restriction and Its Effects on the Long-Term Health of the Child
王雅慧 1王艳 1裴飞2
作者信息
- 1. 150040 哈尔滨,黑龙江中医药大学
- 2. 黑龙江中医药大学附属第二医院
- 折叠
摘要
胎儿生长受限(fetal growth restriction,FGR)是指胎儿在妊娠期内无法达到其预期的生长潜力,其是妊娠期常见且较复杂的并发症之一.FGR病因复杂多样,可能是由母体、胎儿或胎盘因素所引起.对于存在FGR的儿童和成年患者,长期的追踪研究揭示了其健康状况的不良后果.生长受限胎儿的出生体质量和身长明显落后于正常儿童,绝大部分患儿在生后早期即开始出现明显的生长追赶,但其存在更高的代谢问题风险.FGR常常伴随着一系列的远期并发症,如神经系统发育障碍和骨骼肌生长代谢异常等问题,甚至是在成年期时更易出现代谢 综合征和心血管疾病,这对患儿的身体健康和生活质量产生了严重影响.综述FGR致病因素及对患儿远期健康的影响,以期为临床防治提供相关理论支持.
Abstract
Fetal growth restriction(FGR)is one of the common and more complex complications of pregnancy,which refers to the inability of the fetus to reach its expected growth potential during pregnancy.The etiology of FGR is complex and varied,and may be caused by maternal,fetal or placental factors.Long-term follow-up studies of pediatric and adult patients with FGR have revealed adverse health outcomes.Fetuses with growth restriction lag significantly behind normal children in birth weight and length after delivery,and the vast majority of these children begin to experience significant growth catch-up early in life,but are at higher risk for metabolic problems.FGR is often associated with a range of long-term complications,such as neurologic deficits and abnormalities in skeletal muscle growth and metabolism,and is even associated with increased risk of metabolic syndrome and cardiovascular disease in adulthood.This has a serious impact on the physical health and quality of life of children with FGR.We summarize the pathogenic factors of FGR and its effects on the long-term health of children in order to provide theoretical support for the clinical prevention and treatment of FGR.
关键词
胎儿生长迟缓/胚胎发育/神经发育障碍/肌肉骨骼发育/代谢综合征Key words
Fetal growth retardation/Embryonic development/Neurodevelopmental disorders/Musculoskeletal development/Metabolic syndrome引用本文复制引用
基金项目
黑龙江中医药大学"优秀创新人才支持计划"科研项目(2018RCL10)
出版年
2024
国家科技期刊平台
NSTL
万方数据