上皮型钙黏蛋白在卵巢癌腹腔种植转移中的作用
Role of E-Cadherin in Peritoneal Implantation and Metastasis of Ovarian Cancer
齐琦 1高亚婷 1许飞雪2
作者信息
- 1. 730000 兰州大学第一临床医学院
- 2. 兰州大学第一医院妇产科,甘肃省妇科肿瘤临床研究中心
- 折叠
摘要
卵巢癌是女性因癌症死亡的重要原因之一,其预后不良的主要原因是卵巢癌易短期内复发和转移.卵巢癌转移涉及细胞间连接、血管生成、肿瘤微环境等多个方面.研究发现,上皮型钙黏蛋白(E-cadherin)是卵巢癌转移过程中的重要影响因素,其可以通过改变细胞-细胞间黏附、促进血管生成、调节上皮-间质转化进程、促进肿瘤侵袭及浸润来参与卵巢癌的转移.详细阐述E-cadherin的结构及其在卵巢癌中的表达,并就卵巢癌的种植转移机制及E-cadherin在卵巢癌种植转移中的作用进行综述,以期为卵巢癌的复发监测及后续治疗提供新的思路.
Abstract
Ovarian cancer is one of the important causes of cancer death in women,and the main reason for its poor prognosis is that ovarian cancer is prone to recurrence and metastasis in a short period of time.Metastasis of ovarian cancer involves many aspects,such as intercellular junction,angiogenesis,tumor microenvironment and so on.It has been found that epithelial cadherin(E-cadherin)is an important factor in the metastasis of ovarian cancer,which can participate in the metastasis of ovarian cancer by changing cell-cell adhesion,promoting angiogenesis,regulating the process of epithelial-mesenchymal transition,and promoting tumor invasion and infiltration.The structure and expression of E-cadherin in ovarian cancer will be described in detail,and the implantation and metastasis mechanism of ovarian cancer and the role of E-cadherin in ovarian cancer metastasis are reviewed,in order to provide new ideas for recurrence monitoring and follow-up treatment of ovarian cancer.
关键词
钙黏着糖蛋白类/卵巢肿瘤/卵巢上皮癌/肿瘤转移/上皮-间质转化Key words
Cadherins/Ovarian neoplasms/Carcinoma,ovarian epithelial/Neoplasm metastasis/Epithelial-mesenchymal transition引用本文复制引用
基金项目
甘肃省自然科学基金(21JR7RA378)
出版年
2024
国家科技期刊平台
NSTL
万方数据