铜与卵巢癌的研究进展
Research Progress in Copper and Ovarian Cancer
邹乔剑 1姚书忠 1陈怡李 1刘军秀1
作者信息
- 1. 510000 广州,中山大学附属第一医院妇产科
- 折叠
摘要
卵巢癌是常见的妇科恶性肿瘤之一,多数患者在发现时已是晚期,治疗效果及预后差,严重影响患者的生存质量.铜是人体内重要的微量元素,参与多种关键生物过程,并与多种恶性肿瘤的进展密切相关.目前,越来越多的研究探索了铜与卵巢癌的关系,发现卵巢癌患者血浆、腹水及肿瘤组织中铜水平较健康人群明显升高,并且多种铜转运蛋白的异常表达与卵巢癌铂类药物化疗耐药密切相关.近年来,针对铜代谢的抗肿瘤治疗方式成为了研究的热点,大量的研究证明了铜螯合剂和铜离子载体在体内外对卵巢癌的显著抑制作用.综述铜与卵巢癌的密切关系,深入了解基于铜代谢的药物及治疗方法在卵巢癌中的应用,以期为卵巢癌的治疗提供新的方向.
Abstract
Ovarian cancer is one of the common gynecological malignant tumors,and most patients with ovarian cancer are discovered in their advanced stage,their prognosis and treatment effects are usually poor,which also seriously affects the quality of patients'survival.Copper is an important trace element that participates in various important biological processes in human body and correlates closely with the progression of many malignant tumors.An increasing number of studies have explored the relationship between copper and ovarian cancer.Previous research has noticed that copper levels are apparently higher in the plasma,ascites,and tumor tissue of ovarian cancer patients than in healthy women,and the abnormal expressions of a variety of copper-transporting proteins is closely related to the resistance to platinum-based drug chemotherapy in ovarian cancer.Recently,anti-tumor therapy targeting copper metabolism has become a hot research topic.Many studies have demonstrated the significant inhibitory effect of copper chelators and ionophores on ovarian cancer in vitro and in vivo.To summarizes the close relationship between copper and ovarian cancer,and to gain a deeper understanding of the application of copper-metabolism-based drugs and therapies,which may provide new insight into the treatment of ovarian cancer.
关键词
卵巢肿瘤/铜/铜离子转运蛋白类/铜转移三磷酸酶类/抗肿瘤联合化疗方案/顺铂Key words
Ovarian neoplasms/Copper/Copper transport proteins/Copper-transporting ATPases/Antineoplastic combined chemotherapy protocols/Cisplatin引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据