Vulvar angiomyofibroblastoma(AMF)is a rare benign tumor that occurs in women of childbearing age,originating from the vulva or vagina.Liposarcoma typically occurs in the trunk and limbs of perimenopausal and postmenopausal women.We report a case where a large vulvar AMF was initially misdiagnosed as liposarcoma by magnetic resonance imaging(MRI).The patient who was admitted to the hospital because of the discovery of a vulvar mass for 3 years that had enlarged over one year,was diagnosed with liposarcoma via preoperative MRI.However,a preoperative biopsy revealed AMF.The patient underwent excision of vulvar mass and vulvovaginoplasty.Postoperative pathology confirmed the AMF diagnosis,with no recurrence observed during the postoperative follow up for 9 months.Clinicians should enhance the differential diagnosis of such condition and improve the diagnostic accuracy of AMF by combining preoperative histopathology and related imaging examinations,providing accurate clinical information for surgical guidance.