国际妇产科学杂志2024,Vol.51Issue(3) :279-283.DOI:10.12280/gjfckx.20230955

干细胞外泌体在妇科疾病中的临床应用

Clinical Application of Stem Cell-Derived Exosomes in Gynecological Diseases

郭世为 孙静莉 陈震宇 刘森
国际妇产科学杂志2024,Vol.51Issue(3) :279-283.DOI:10.12280/gjfckx.20230955

干细胞外泌体在妇科疾病中的临床应用

Clinical Application of Stem Cell-Derived Exosomes in Gynecological Diseases

郭世为 1孙静莉 2陈震宇 2刘森3
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作者信息

  • 1. 110003 沈阳,北部战区总医院大连医科大学研究生培养基地
  • 2. 北部战区总医院和平院区妇产科
  • 3. 北部战区总医院锦州医科大学研究生培养基地
  • 折叠

摘要

干细胞外泌体(stem cell-derived exosome,SC-Exo)是从干细胞中释放的一种微小囊泡,不同细胞或组织来源的外泌体在疾病的发生发展过程中起到不同的作用,已在临床各领域取得重要的成果和进展,其在复发性流产、多囊卵巢综合征、卵巢功能减退、宫腔粘连、阴道手术创面修复、妇科肿瘤和盆底功能障碍等妇科疾病中的应用价值正不断被发掘.SC-Exo可通过释放核酸、蛋白质、脂质和细胞因子等多种生物活性分子,介导靶向细胞间的信号传递及遗传信息的功能转移,对妇科相关疾病的治疗具有潜在的益处,是一种新颖而有前途的治疗策略.

Abstract

Stem cell-derived exosomes(SC-Exo)are petite vesicles,released from stem cells.Exosomes originating from different cells or tissues play diverse roles in the pathogenesis and progression of diseases,and have made significant achievements and progress in various clinical fields.The application value of SC-Exo in gynecological diseases such as recurrent spontaneous abortion,polycystic ovary syndrome,premature ovarian insufficiency,intrauterine adhesions,wound repair in vaginal surgery,gynecological tumors and pelvic floor dysfunction is increasingly being recognized.SC-Exo can mediate the signaling and functional transfer of genetic information between targeted cells by releasing a variety of bioactive molecules such as nucleic acids,proteins,lipids and cytokines.It has potential benefits for the treatment of gynecological diseases and is a novel and promising therapeutic strategy.

关键词

干细胞/外泌体/生殖器疾病,女(雌)性/间质干细胞/微RNAs

Key words

Stem cells/Exosomes/Genital diseases,female/Mesenchymal stem cells/MicroRNAs

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出版年

2024
国际妇产科学杂志
天津市医学科学技术信息研究所

国际妇产科学杂志

CSTPCD
影响因子:1.155
ISSN:1674-1870
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