Pre-eclampsia is a leading cause of maternal and newborn mortality worldwide,impacting long-term health outcomes for both mother and child.We describe and analyze the limitations and controversies related to using aspirin for pre-eclampsia prevention,and explore the involvement of other medications in preventative strategies.Furthermore,this article examines the pre-eclampsia prediction scheme for both singleton and twin pregnancies,emphasizing the importance of tertiary referral systems in the prevention and treatment of pre-eclampsia,aiming to further promoting high-quality pre-eclampsia prevention and treatment and improve maternal and child health in China.