外泌体在卵巢癌血管生成中的研究进展
Research Advances of Exosomes in Angiogenesis of Ovarian Cancer
张静怡 1刘东哲 2陈秀慧1
作者信息
- 1. 150000 哈尔滨医科大学附属第二医院妇产科
- 2. 深圳大学总医院血液肿瘤科
- 折叠
摘要
在卵巢癌的治疗过程中,肿瘤细胞往往会对化疗药物产生耐药性,导致治疗效果减弱或消失.因此,抗血管生成治疗作为一种重要的维持治疗手段,通过不同的机制与其他治疗方法协同作用,可以有效减慢疾病进展速度.外泌体是由活细胞分泌的细胞外囊泡,携带着多种遗传物质,在肿瘤微环境中起着细胞通信的重要作用.研究发现,肿瘤细胞及其他细胞来源的外泌体可以通过释放非编码RNA、蛋白质等遗传物质影响血管生成及其他肿瘤相关过程.利用外泌体靶向特定蛋白或作为包裹治疗剂的外源性载体,已经成为卵巢癌抗血管生成治疗的重要策略.综述外泌体对卵巢癌血管生成的调控机制,以及其作为抗血管生成剂的作用潜力,以期为新的治疗方法提供理论依据.
Abstract
In the treatment of ovarian cancer,tumor cells often become resistant to chemotherapy drugs,leading to weakened or ineffective treatment outcomes.Therefore,anti-angiogenesis therapy serves as an important adjunctive treatment,can effectively slow disease progression by synergizing with other treatment modalities through various mechanisms.Exosomes,extracellular vesicles secreted by living cells,carry a variety of genetic materials and play crucial roles in cell communication within the tumor microenvironment.Studies have shown that exosomes derived from tumor cells and other cell sources can influence angiogenesis and other tumor-related processes by releasing non-coding RNAs,proteins,and other genetic materials.Utilizing exosomes to target specific proteins or as exogenous carriers for encapsulate therapeutic agents has become an important strategy for anti-angiogenesis therapy in ovarian cancer.This review summarized the regulatory mechanism of exosomes on angiogenesis in ovarian cancer and it also explores the potential of exosomes as anti-angiogenic agents,providing a theoretical basis for new treatment methods.
关键词
外泌体/卵巢肿瘤/新生血管化/治疗/肿瘤微环境Key words
Exosomes/Ovarian neoplasms/Neovascularization/Therapy/Tumor microenvironment引用本文复制引用
基金项目
国家自然科学基金(81802592)
中国博士后科学基金会基金(2018M641854)
出版年
2024
国家科技期刊平台
NSTL
万方数据