Uterine leiomyosarcoma(uLMS)is one of the most common uterine sarcomas with features such as chromosome instability,strong invasiveness and poor prognosis.The diagnosis of uLMS is mainly based on histopathology,with a lack of specificity in other auxiliary examination techniques.In recent years,with the maturation of high-throughput sequencing technology,genomics has witnessed rapid development in the research on the pathogenesis of uLMS,uncovering multiple gene-specific molecular alterations such as gene upregulation,downregulation,mutations,and gene fusions.This review will systematically introduce the latest progress of uLMS in genomics research.The goal is to construct a multi-angle and multi-faceted heterogenetic map of uLMS,and provide basis and direction for the accurate and early diagnosis of uLMS at the molecular level as well.
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