Polycystic ovary syndrome(PCOS)is a common and complex gynecological endocrine disorder that mainly affects women of childbearing age.Its main characteristics include ovulation disorders,insulin resistance and hyperandrogenemia.The mitogen-activated protein kinase(MAPK)signaling pathway plays an important role in the occurrence of PCOS.It has been confirmed that the three classic MAPK pathways-extracellular signal-regulated kinase(ERK),c-Jun N-terminal kinase(JNK),and p38 MAPK are closely related to the occurrence of PCOS.Once these pathways are abnormally activated,it will prompt the body to have a variety of adverse reactions and ultimately lead to PCOS.Specifically,it includes ovulation dysfunction,insulin resistance,elevated androgen levels,oxidative stress and inflammatory reactions.Studies have shown that a variety of traditional Chinese medicine monomers can regulate the activity and expression of MAPK signaling pathway-related proteins.These traditional Chinese medicine monomers include flavonoids,glycosides,terpenoids,alkaloids and polysaccharides.Through this modulation,they can effectively improve the pathophysiological process of PCOS patients,thus providing new ideas and methods for the treatment of PCOS.
关键词
多囊卵巢综合征/丝裂原激活蛋白激酶类/中药单体/胰岛素抵抗/雄激素增多症
Key words
Polycystic ovary syndrome/Mitogen-activated protein kinases/Traditional Chinese medicine monomers/Insulin resistance/Hyperandrogenism
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