Premenstrual dysphoria disorder(PMDD)is a common disease that endangers the health of women of childbearing age.with a high prevalence of suicidal tendencies in severe cases,and the sensitivity of ovarian steroid hormone fluctuations may be its core pathogenesis.In clinical practice,PMDD patients are plagued by both mental and physical symptoms,but previous studies have often focused on emotional changes such as depressive disorders,neglecting physical accompanying symptoms such as breast tenderness and migraine.Migraine itself is affected by fluctuations in female estrogen levels and exhibits different individual sensitivities,and the use of antidepressants in pain treatment can also be seen clinically.Previous studies have shown that depression pain may have a common pathological basis,and estrogen fluctuations regulate the pathological changes of both.This paper reviews the basis of depression-pain occurrence in PMDD from the perspective of estrogen fluctuations,in order to provide reference for exploring the core pathogenesis and promote the development of antidepressant pain comorbidity drugs.
关键词
经前烦躁障碍症/抑郁/疼痛/雌激素类/降钙素基因相关肽
Key words
Premenstrual dysphoria disorder/Depression/Pain/Estrogens/Calcitonin gene related peptide
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