FLASH放疗技术对正常组织保护效应和肿瘤治疗效果的研究进展
Research progress of FLASH radiotherapy on protective effect for the normal tissue and the therapeutic effect for the tumor tissue
陈欢 1郇福奎 1门阔 1戴建荣 1任雯廷1
作者信息
- 1. 国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院放疗科,北京 100021
- 折叠
摘要
超高剂量率(FLASH)放疗是一种新型的放疗技术,其已成为近6年放疗领域备受关注的新兴革命性技术之一.FLASH放疗具有很好的正常组织保护效应且不影响肿瘤的放疗效果.同时,FLASH放疗的射线曝光时间极短,可消除器官或肿瘤运动对治疗精确度的影响,提升治疗的精准度和患者的舒适度,有可能彻底改变恶性肿瘤治疗的现状.目前,FLASH放疗对正常组织保护效应的内在机制尚不清楚.笔者从正常组织保护效应和肿瘤治疗效果两个方面归纳总结FLASH放疗的研究进展,概括了 FLASH放疗对正常组织保护效应的可能的生物学机制,为FLASH放疗的进一步研究提供参考.
Abstract
Ultra-high dose rate(FLASH)radiotherapy is an innovation radiotherapy technique that has emerged as one of the revolutionary technologies in the field of radiotherapy over the past six years.It demonstrates excellent normal tissue protective effects without compromising the therapeutic efficacy on tumors.Moreover,the extremely short delivery time of FLASH radiotherapy helps eliminate the impact of organ or tumor motion on treatment accuracy,thereby enhancing treatment precision and patient comfort.This technology holds the potential to fundamentally transform the landscape of malignant tumor treatment.Currently,the underlying mechanism of the protective effects of FLASH radiotherapy on normal tissues are not fully understood.The authors present provide a comprehensive overview of the research progress in FLASH radiotherapy,encompassing both normal tissue protection and tumor treatment effects.Additionally,this paper provides insights into the potential biological mechanisms underlying the protection effects of FLASH radiotherapy.Consequently this paper serves as a valuable reference for further research in the field of FLASH radiotherapy.
关键词
放射疗法/超高剂量率/正常组织/肿瘤治疗Key words
Radiotherapy/Ultra-high dose rate/Normal tissue/Cancer treatment引用本文复制引用
基金项目
中国医学科学院医学与健康科技创新工程(2022-12M-C&T-B-074)
国家重点研发计划(2022-I2M-C&T-B-074)
出版年
2024
NETL
NSTL
万方数据