18F-FDG PET/CT在IgG4相关心血管疾病中的应用进展
Research progress of 18F-FDG PET/CT in IgG4 related cardiovascular diseases
宋乐乐 1邱永康 1张潇月 1康磊1
作者信息
- 1. 北京大学第一医院核医学科,北京 100034
- 折叠
摘要
免疫球蛋白G4相关疾病(IgG4-RD)是一种全身炎症性疾病,通常累及多个器官.IgG4相关心血管疾病(IgG4-RCVD)包括IgG4相关主动脉病变、IgG4相关冠状动脉病变、IgG4相关肺动脉病变和IgG4相关心包炎.IgG4-RCVD受累部位IgG4阳性浆细胞聚集并高表达葡萄糖转运蛋白.18F-氟脱氧葡萄糖(FDG)PET/CT可以基于IgG4-RCVD患者病变部位的代谢程度在全身范围内评估血管炎症的范围和程度,在诊断和定量评估IgG4-RCVD血管炎症、指导活检部位选择以及疗效监测等方面起到关键作用.笔者对18F-FDG PET/CT在IgG4-RCVD应用中的进展进行综述,以期为临床医师通过18F-FDG PET/CT诊断IgG4-RCVD提供参考.
Abstract
Immunoglobulin G4-related disease(IgG4-RD)is a type of systemic inflammatory diseases that often affect multiple organs.IgG4-related cardiovascular disease(IgG4-RCVD)includes IgG4-related aortic disease,IgG4-related coronary artery disease,IgG4-related pulmonary artery disease,and IgG4-related pericarditis.IgG4-positive plasma cells accumulate and exhibit high expression of glucose transport proteins at the site of IgG4-RCVD involvement.18F-fluorodeoxyglucose(FDG)PET/CT can assess the extent and degree of vascular inflammation on a systemic scale by evaluating the metabolic activity of lesions in IgG4-RCVD patients.It plays a pivotal role in diagnosing and quantitatively assessing IgG4-RCVD vascular inflammation,aiding in the selection of biopsy sites,and monitoring treatment efficacy.The authors conducted a comprehensive review of the advancements in the utilization of 18F-FDG PET/CT for IgG4-RCVD,aiming to furnish clinicians with a valuable reference for diagnosing IgG4-RCVD through the application of 18F-FDG PET/CT.
关键词
氟脱氧葡萄糖F18/正电子发射断层显像术/体层摄影术,X线计算机/免疫球蛋白G4相关疾病/免疫球蛋白G4相关心血管疾病Key words
Fluorodeoxyglucose F18/Positron-emission tomography/Tomography,X-ray computed/Immunoglobulin G4-related disease/Immunoglobulin G4-related cardiovascular disease引用本文复制引用
基金项目
国家自然科学基金面上项目(82171970)
北京市杰出青年科学基金(JQ21025)
北京市科委首都临床特色应用研究项目(Z221100007422027)
出版年
2024
NETL
NSTL
万方数据