首页|18F-FDG PET/CT在IgG4相关心血管疾病中的应用进展

18F-FDG PET/CT在IgG4相关心血管疾病中的应用进展

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免疫球蛋白G4相关疾病(IgG4-RD)是一种全身炎症性疾病,通常累及多个器官.IgG4相关心血管疾病(IgG4-RCVD)包括IgG4相关主动脉病变、IgG4相关冠状动脉病变、IgG4相关肺动脉病变和IgG4相关心包炎.IgG4-RCVD受累部位IgG4阳性浆细胞聚集并高表达葡萄糖转运蛋白.18F-氟脱氧葡萄糖(FDG)PET/CT可以基于IgG4-RCVD患者病变部位的代谢程度在全身范围内评估血管炎症的范围和程度,在诊断和定量评估IgG4-RCVD血管炎症、指导活检部位选择以及疗效监测等方面起到关键作用.笔者对18F-FDG PET/CT在IgG4-RCVD应用中的进展进行综述,以期为临床医师通过18F-FDG PET/CT诊断IgG4-RCVD提供参考.
Research progress of 18F-FDG PET/CT in IgG4 related cardiovascular diseases
Immunoglobulin G4-related disease(IgG4-RD)is a type of systemic inflammatory diseases that often affect multiple organs.IgG4-related cardiovascular disease(IgG4-RCVD)includes IgG4-related aortic disease,IgG4-related coronary artery disease,IgG4-related pulmonary artery disease,and IgG4-related pericarditis.IgG4-positive plasma cells accumulate and exhibit high expression of glucose transport proteins at the site of IgG4-RCVD involvement.18F-fluorodeoxyglucose(FDG)PET/CT can assess the extent and degree of vascular inflammation on a systemic scale by evaluating the metabolic activity of lesions in IgG4-RCVD patients.It plays a pivotal role in diagnosing and quantitatively assessing IgG4-RCVD vascular inflammation,aiding in the selection of biopsy sites,and monitoring treatment efficacy.The authors conducted a comprehensive review of the advancements in the utilization of 18F-FDG PET/CT for IgG4-RCVD,aiming to furnish clinicians with a valuable reference for diagnosing IgG4-RCVD through the application of 18F-FDG PET/CT.

Fluorodeoxyglucose F18Positron-emission tomographyTomography,X-ray computedImmunoglobulin G4-related diseaseImmunoglobulin G4-related cardiovascular disease

宋乐乐、邱永康、张潇月、康磊

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北京大学第一医院核医学科,北京 100034

氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术,X线计算机 免疫球蛋白G4相关疾病 免疫球蛋白G4相关心血管疾病

国家自然科学基金面上项目北京市杰出青年科学基金北京市科委首都临床特色应用研究项目

82171970JQ21025Z221100007422027

2024

10.3760/cma.j.cn121381-202303013-00390

国际放射医学核医学杂志
中华医学会 中国医学科学院放射医学研究所

国际放射医学核医学杂志

CSTPCD
影响因子：0.227
ISSN：1673-4114
年,卷(期)：2024.48(4)
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