成纤维细胞活化蛋白抑制剂PET/CT在非肿瘤疾病中的应用进展
Application progress of fibroblast activation protein inhibitors PET/CT in non-tumor diseases
郑钰州 1施冬梅 1郝新忠 1王红亮1
作者信息
- 1. 山西医科大学第一医院核医学科,太原 030001
- 折叠
摘要
成纤维细胞活化蛋白(FAP)是一种具有二肽基肽酶和内肽酶活性的丝氨酸蛋白酶,常在肿瘤相关成纤维细胞中过表达.目前,放射性核素标记的成纤维细胞活化蛋白抑制剂(FAPI)PET/CT在肿瘤中的应用成为核医学研究的新热点.然而,FAP在活化的成纤维细胞中亦高表达,有关FAPIPET/CT在非肿瘤疾病(如心肌梗死、间质性肺纤维化疾病及免疫球蛋白G4相关疾病等)方面的研究取得了一定进展,且在疾病的早期诊断及疗效评估中具有潜在的应用前景.笔者就FAPIPET/CT在非肿瘤疾病中的应用及研究进展进行综述.
Abstract
Fibroblast activation protein(FAP)is a serine protease with dipeptidyl peptidase and endopeptidase activities,often overexpressed in tumor-associated fibroblasts.Currently,the use of radioisotope-labeled fibroblast activation protein inhibitors(FAPI)PET/CT in tumors has become a new hot spot in nuclear medicine research.However,FAP is also highly expressed in activated fibroblasts,and there has been some progress in the application of FAPI PET/CT in non-tumor diseases(such as myocardial infarction,interstitial pulmonary fibrosis diseases,and immunoglobulin G4-related diseases,etc),holding potential for in the early diagnosis and efficacy evaluation of these diseases.The authors review of the application and research progress of FAPI PET/CT in non-tumor diseases.
关键词
正电子发射断层显像术/体层摄影术,X线计算机/成纤维细胞活化蛋白/心肌纤维化/肺纤维化/肾脏纤维化Key words
Positron-emission tomography/Tomography,X-ray computed/Fibroblast activation protein/Myocardial fibrosis/Pulmonary fibrosis/Renal fibrosis引用本文复制引用
基金项目
山西省基础研究计划(202103021224409)
山西省研究生教育创新项目(2021Y434)
山西省研究生教育教学改革项目(2021YJJG116)
出版年
2024
NETL
NSTL
万方数据