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18F-MFBG的制备及临床应用进展

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123I-间碘苄胍(123I-MIBG)是去甲肾上腺素类似物,能够与去甲肾上腺素转运蛋白特异性结合,可用于神经内分泌肿瘤SPECT显像、心脏交感神经SPECT显像及帕金森病的头部显像.但123I-MIBG的不足之处限制了其临床应用,国内外研究者的多项研究结果表明18F-间氟苄胍(18F-MFBG)是最有望代替123I-MIBG的显像剂.笔者就18F-MFBG的制备及临床应用进展进行综述.
Progress in preparation and clinicl application of18F-MFBG
123I-meta-iodobenzylguanidine(123I-MIBG)is a norepinephrine analog that can specifically bind to norepinephrine transporter and can be used for SPECT imaging of neuroendocrine tumors,SPECT imaging of cardiac sympathetic nerves and head imaging of Parkinson's disease.However,the shortcomings of 123I-MIBG limit its clinical application.Several research results from domestic and foreign researchers have shown that 18F-meta-fluorobenzidine(18F-MFBG)is the most promising imaging agent to replace 123I-MIBG.The author reviews the progress in the preparation and clinical application of 18F-MFBG.

18F labeled compoundFluorobenzenesNorepinephrine plasma membrane transport proteinsIsotope labelingFluorine radioisotopesPositron-emission tomographyNeuroendocrine neoplasmsMyocardial imaging

李帅

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天津医科大学总医院PET/CT影像诊断科,天津 300052

氟-18标记物 氟苯类 去甲肾上腺素质膜转运蛋白质类 同位素标记 氟放射性同位素 正电子发射断层显像术 神经内分泌肿瘤 心肌显像

2024

10.3760/cma.j.cn121381-202404033-00475

国际放射医学核医学杂志
中华医学会 中国医学科学院放射医学研究所

国际放射医学核医学杂志

CSTPCD
影响因子：0.227
ISSN：1673-4114
年,卷(期)：2024.48(11)