目的 探讨肠道微生物群与维生素D缺乏之间的关联,特别是识别与维生素D缺乏风险相关的特定肠道微生物.方法 分析了肠道微生物群与维生素D缺乏全基因组关联研究的汇总统计数据.主要使用逆方差加权(inverse variance weighted,IVW)方法进行孟德尔随机化分析评估肠道微生物群属水平与维生素D缺乏之间的因果关系.通过综合敏感性分析用于验证结果的稳健性、异质性和水平多效性.结果在不存在异质性和水平多效性的情况下,IVW分析方法显示霍尔德曼氏菌属(Holdemania)(OR=1.524,95％CI=1.001～2.231,P=0.049)、阿里松氏菌属(Allisonella)(OR=1.597,95％CI=1.095～2.329,P=0.015)、埃希菌-志贺氏菌属(Escherichia-Shigella)(OR=2.000,95％CI=1.156～3.463,P=0.013)以及毛螺菌科 NC2004 组(Lachnospiraceae NC2004 group)(OR=2.106),95％CI=1.178～3.766,P=0.012)与维生素 D 缺乏风险正相关.而毛螺菌属(Lachnospira)(OR=0.324,95％CI=0.124～0.844,P=0.021)和 Tyzzerella 3 属(OR=0.591,95％CI=0.406～0.861,P=0.006)与维生素 D 缺乏呈负相关.结论 研究发现肠道微生物群某些菌株的丰度与维生素D缺乏风险有关.这一发现为维生素D缺乏预防和治疗提供了潜在靶点.
Causal Relationship Between Gut Microbiota and Vitamin D Deficien-cy:A Two-sample Mendelian Randomization Study
Objective To investigate the association between gut microbiota and vitamin D de-ficiency,and to identify specific gut microbial taxa related to the risk of vitamin D deficien-cy.Methods Data from genome-wide association studies(GWAS)on gut microbiota and vitamin D deficiency were summarized and analyzed.Inverse variance weighted(IVW)method was used for Mendelian randomization analysis to assess the causal relationship between gut microbiota taxa and vitamin D deficiency.Sensitivity analyses were conducted to evaluate heterogeneity,pleiotropy,and robustness of the results.Results In the absence of heterogeneity and horizontal pleiotropy,the IVW analysis method that showed Holdemania(OR=1.524,95％CI=1.001-2.231,P=0.049),Allisonella(OR=1.597,95％CI=1.095-2.329,P=0.015),Escherichia-Shigella(OR=2.000,95％CI=1.156-3.463,P=0.013),and Lachnospiraceae NC2004 group(OR=2.106,95％CI=1.178-3.766,P=0.012)were positively associated with the risk of vitamin D deficiency.While the Lachnospira(OR=0.324,95％CI=0.124-0.844,P=0.021)and Tyzz-erella3(OR=0.591,95％CI=0.406-0.861,P=0.006)were negatively associated with the risk of vitamin D deficiency.Conclusion This study found significant correlations between the a-bundance of certain specific strains in the gut microbiota and the risk of vitamin D deficiency.This discovery may provide new potential targets for the prevention and treatment of vitamin D deficiency.
vitamin D deficiencyMendelian randomizationgut microbiotacausal effects
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