Progress in research on phosphoinositide 3-kinase/protein kinase B pathway inhibitors in oral squamous cell carci-noma
Oral squamous cell carcinoma(OSCC)is an oral and maxillofacial tumor with a high incidence rate and is a serious threat to human health.The phosphoinositide 3-kinase/protein kinase B pathway affects disease progression in va-rious cancer types.Given that this pathway is frequently activated in OSCC,it is a candidate pathway for therapeutic inter-ventions for OSCC.Thus,inhibitors targeting this pathway are currently being developed.This article focuses on current progress in research on this pathway and discusses the recent status of research on drugs targeting it.
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