Effects of cannabinoid type Ⅰ receptor inhibition and activation on hard-palate mucosal wound healing in rats
Objective This study aimed to analyze the effect of the inhibition or activation of cannabinoid type Ⅰ receptor(CBlR)on wound healing of hard-palate mucosa in rats.Methods The hard-palate mucosa in rats was traumatized with a 2 mm punch,and rimonabant hydrochloride(SR141716A)or anandamide(AEA)was injected intraperitoneally for 7 days.Wound plane healing,histological healing,and the expression level of CB1R were recorded,and the cytokine concentration of tissue homogenate was detected by enzyme-linked immunosorbent assay.Results The expression level of CB1R protein affects the healing of hard-palate mucosa wounds.The wounds of animals with the inhibition of CB1R showed healing delay,accompanied with the increased expression level of tumor necrosis factor-α and monocyte chemotactic protein-1.Conclusion CB1R is expressed in the surrounding tissues during hard-palate mucosal trauma in rats,which reduces the level of inflammation in local tissues and promotes wound healing.
wound healingcannabinoid type Ⅰ receptorhard-palate mucosa
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