Smart responsive hydrogels and their application in controlled drug release
Hydrogels are polymeric materials with advantageous properties of facile functionalization and drug encap-sulation,rendering them applicable in drug delivery.Compared with regular hydrogels,smart responsive hydrogels are su-perior drug delivery systems due to their ability to intelligently respond to stimuli and avoid burst drug release in the early stage.These hydrogels can effectively react to microenvironmental alterations in disease conditions or external stimuli,hence enabling precise and timely controlled drug release.In this work,the unique response mechanism of hydrogels re-sponsive to pH,reactive oxygen species,chemical,temperature,magnetic,light and ultrasound and their innovative appli-cation in the treatment of various diseases are reviewed.The findings present the frontier progress in this field and point out the development direction of future research.
hydrogelssmart responsive hydrogelsdrug deliverycontrolled drug release
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