Dynamic changes and clinical significance of interleukin-6 in serum and bronchoalveolar lavage fluid of patients with COVID-19
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目的 探讨COVID-19患者血清和肺泡灌洗液（bronchoalveolar lavage fluid，BALF）中IL-6的动态变化及与临床预后关系。 方法 选取2020年1月至2023年5月龙游县人民医院重症医学科收治的48例COVID-19患者作为试验组，并选取同时间段45例非COVID-19病毒性肺炎患者作为对照组，分别监测两组患者血清和BALF中的IL-6水平。根据临床预后情况将试验组分为好转组（26例）和恶化组（22例），分析两组患者血清和BALF中IL-6的变化，并在病程第10天计算临床肺部感染评分（CPIS），分析IL-6与CPIS的相关性。 结果 试验组患者血清和BALF中IL-6水平分别为(24.90 ± 7.56) pg/mL和(79.46 ± 23.81) pg/mL，均高于对照组的(3.60±1.36 ) pg/mL和（28.29±10.87） pg/mL，差异有统计学意义（t =19.203和13.466，P均< 0.001）。COVID-19患者组内比较，好转组患者血清和BALF中IL-6水平分别为（22.73± 5.72） pg/mL和（72.58 ± 18.23） pg/mL，均低于恶化组[（27.45 ± 8.72） pg/mL和(87.59 ± 27.31) pg/mL]，差异有统计学意义（t = -2.175和-2.198，P = 0.029和0.028）。相关性分析结果显示，IL-6水平与COVID-19患者的CPIS呈显著正相关（r=0.760~0.905, P < 0.001）。 结论 IL-6能反映COVID-19的严重程度，且与患者的预后密切相关，IL-6水平越高提示预后越差。 Objective To explore the dynamic changes of IL-6 in serum and bronchoalveolar lavage fluid (BALF) of patients with COVID-19 and its correlation with clinical prognosis. Methods From January 2020 to May 2023, 48 COVID-19 patients admitted to intensive care unit of Longyou County People's Hospital were selected as the experimental group, and 45 patients with non-COVID-19 viral pneumonia in the same period were selected as the control group. IL-6 levels in serum and BALF were detected in both groups. According to clinical prognosis, the experimental group was divided into the improved group (26 cases) and the deteriorated group (22 cases), and the changes of IL-6 in serum and BALF of the two groups were analyzed. On the 10th day of illness, the clinical pulmonary infection score (CPIS) was calculated, and its correlation with IL-6 was analyzed. Results The levels of IL-6 in the serum and BALF in the experimental group were (24.90±7.56) pg/mL and (79.46±23.81) pg/mL, respectively, which were significantly higher than those in the control group [(3.60±1.36) pg/mL and (28.29±10.87) pg/mL](t=19.203 and 13.466, P < 0.001). Among COVID-19 patients, the IL-6 levels in serum and BALF in the improved group were (22.73± 5.72) pg/mL and (72.58 ± 18.23) pg/mL, respectively, which were significantly lower than those in the deterioratd group [(27.45±8.72) pg/mL and (87.59±27.31) pg/mL]( t=-2.175 and -2.198, P=0.029 and 0.028). Correlation analysis revealed a significant positive correlation between IL-6 levels and CPIS of COVID-19 patients (r=0.760-0.905, P<0.001). Conclusions The level of IL-6 can reflect the severity of COVID-19 and is closely related to the patient's prognosis. Higher levels of IL-6 indicate a poorer prognosis.
Objective To explore the dynamic changes of IL-6 in serum and bronchoalveolar lavage fluid (BALF) of patients with COVID-19 and its correlation with clinical prognosis. Methods From January 2020 to May 2023, 48 COVID-19 patients admitted to intensive care unit of Longyou County People's Hospital were selected as the experimental group, and 45 patients with non-COVID-19 viral pneumonia in the same period were selected as the control group. IL-6 levels in serum and BALF were detected in both groups. According to clinical prognosis, the experimental group was divided into the improved group (26 cases) and the deteriorated group (22 cases), and the changes of IL-6 in serum and BALF of the two groups were analyzed. On the 10th day of illness, the clinical pulmonary infection score (CPIS) was calculated, and its correlation with IL-6 was analyzed. Results The levels of IL-6 in the serum and BALF in the experimental group were (24.90±7.56) pg/mL and (79.46±23.81) pg/mL, respectively, which were significantly higher than those in the control group [(3.60±1.36) pg/mL and (28.29±10.87) pg/mL](t=19.203 and 13.466, P < 0.001). Among COVID-19 patients, the IL-6 levels in serum and BALF in the improved group were (22.73± 5.72) pg/mL and (72.58 ± 18.23) pg/mL, respectively, which were significantly lower than those in the deterioratd group [(27.45±8.72) pg/mL and (87.59±27.31) pg/mL]( t=-2.175 and -2.198, P=0.029 and 0.028). Correlation analysis revealed a significant positive correlation between IL-6 levels and CPIS of COVID-19 patients (r=0.760-0.905, P<0.001). Conclusions The level of IL-6 can reflect the severity of COVID-19 and is closely related to the patient's prognosis. Higher levels of IL-6 indicate a poorer prognosis.
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