Progress in animal models of hepatitis E virus infection
耿家宝 1熊熙 2缪幼菡 3赵卫峰4
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作者信息
1. 苏州大学附属第一医院感染病科，苏州 215000;现在东部战区总医院秦淮医疗区感染科工作
2. 东部战区总医院感染病科/肝病中心，南京 210002
3. 南通市第三人民医院感染病科，南通 226000
4. 苏州大学附属第一医院感染病科，苏州 215000
折叠
摘要
戊型肝炎是由HEV引起的常见传染病，它的动物宿主比较广泛，在散发性病例发生过程发挥重要作用。研究HEV动物宿主、实验感染动物模型，对戊型肝炎的防控、HEV致病机制、跨物种传播、疫苗及治疗方案评估等相关研究具有现实意义。本文将对HEV常见动物宿主、实验感染动物模型进行综述。 Hepatitis E is a common infectious disease caused by HEV. HEV has a wide range of animal hosts playing an important role in occurrence of sporadic hepatitis E. The study of animal hosts and animal models of HEV infection has important practical significance for the prevention and control of hepatitis E, as well as for understanding the pathogenic mechanisms of HEV, cross species transmission, vaccine and treatment evaluation and other related research. This article reviews the common animal hosts of HEV and animal models of HEV infection.
Abstract
Hepatitis E is a common infectious disease caused by HEV. HEV has a wide range of animal hosts playing an important role in occurrence of sporadic hepatitis E. The study of animal hosts and animal models of HEV infection has important practical significance for the prevention and control of hepatitis E, as well as for understanding the pathogenic mechanisms of HEV, cross species transmission, vaccine and treatment evaluation and other related research. This article reviews the common animal hosts of HEV and animal models of HEV infection.
关键词
戊型肝炎病毒/动物宿主/实验感染/动物模型
Key words
Hepatitis E virus/Animal host/Experimental infection/Animal model
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