Objective To investigate the clinical characteristics and antiretroviral therapy(ART)outcomes in HIV/HBV co-infected patients with different HBV genotypes,and to explore the potential impact of HBV genotypes on HIV/HBV co-infection.Methods HIV/HBV co-infected patients attending the infectious disease outpatient clinic at Guangzhou Eighth People's Hospital,Guangzhou Medical University from 2009 to 2020 were enrolled.Clinical characteristics and virological,immunological,and clinical responses after ART were compared between genotype B and C HBV-infected patients.Results A total of 722 patients were included in the study,among whom 496 cases(68.70％)were HBV genotype B,220 cases(30.47％)were genotype C,2 cases(0.28％)were genotype D,and 4 cases(0.55％)were genotype Ⅰ.Baseline HBV DNA load and HBeAg positive rate in genotype B patients were 6.29 lg IU/mL and 36.49％(181/496),respectively,which were both lower than those in genotype C patients;and HBsAg quantitative level was 5 478.50 COI,which was higher than that in genotype C patients(Z=-2.989,P=0.003;x2=31.680,P＜0.001;Z=-0.848,P＜0.001).The proportions of patients in both groups receiving ART containing tenofovir disoproxil fumarate and lamivudine were ≥95％.After an average of 4.17 years of ART,virological suppression rates for HIV and HBV were both＞94％in genotype B and C groups.The rate of HBsAg seroconversion during follow-up period was 7.25％(36/496)in genotype B patients,which was higher than that in genotype C patients(x2=5.291,P=0.021).Compared with patients with genotype C,patients with genotype B had higher HBsAg decline of 372.00 COI(Z=-0.018,P=0.032).Conclusions Genotype B and C are predominant in HIV/HBV co-infected individuals in Guangdong Province.All patients with genotype B or C can achieve excellent viral suppression and immune reconstruction after ART.However,genotype C individuals have a lower HBsAg seroconversion rate than genotype B individuals,which indicates that different HBV genotypes may affect the HBV cure in HIV/HBV co-infected patients.
HIVHepatitis B virusGenotypeImmune reconstitutionAntiretroviral therapyVirus inhibition
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